After a pandemic hiatus, the West Coast Structural Biology Workshop (WCSBW) will return. March 2023 will present the 25th meeting of this historic and influential workshop focusing on methods developments in structural biology. Driven by rapid advances in the field, the workshop will encompass the latest methods for structural analysis. With the exception of our two keynote speakers (Profs. Juli Feigon and Robert Stroud), following the meeting’s traditional format, talks will be almost exclusively by graduate students and postdocs presenting their leading work. Posters and oral presentations will emphasize the technical challenges and achievements enabling successful structural analysis. In addition to research talks and posters, the meeting will feature two hands-on workshops on: (1) advances in cryo-EM structure determination protocols, and (2) an introduction to coding neural networks. As in past years, the meeting will be held at the beautiful Asilomar Conference Center in Pacific Grove, CA. This idyllic venue and the interactive spirit of the WCSBW meeting offer wonderful opportunities for interactions between current and future leaders in structural biology.